Laboratory of Structural Biology and Cell Signaling

2021/11/25:
Highly productive collaboration with Angel Pey led to another publication on mammalian NQO1 flavoproteins. This time on phosphorylation and a specific evolutionary divergent mutation close to it. Available in FEBS Letters. Thanks to EU_FT-ICR_MS H2020 Project for support!
2021/11/04:
Our systematic structural characterization of haptoglobin-hemoglobin interaction resulted in a first paper, Hp-Hb interaction studied by FPOP.
2021/09/23:
Congratulations to Honza (Fiji), now officially PhD in biochemistry!
2021/09/22:
Active and productive collaboration with Sergei Strelkov's lab resulted in another paper on lamin assembly. Work was done under EU_FT-ICR_MS H2020 Project.
2021/09/01:
After several years of post-docking in Hamburg, Alan returns to our lab. Welcome home Alan!
2021/08/20:
Great collaboration with Angel Luis Pey from the University of Granada resulted in a very nice multidisciplinary study on the effect of mutations in human flavoproteins. Now available in Redox Biology! Thanks to EU_FT-ICR_MS H2020 Project for support!

2021/11/11:
EPIC-XS organizes another free webinar. This time, super exciting, on Top-Down Proteomics, will be on Dec 15, 2021. Check IP web site for details.
2021/10/04:
Call for EPIC-XS proposals was closed on Sep 30. Due to limited number of slots remaining at the individual TNA sites, we expect next call in spring 2022. Check the EPIC TNA site for details/updates.
2021/04/27:
We are looking for post-doc with knowledge of excimer lasers and/or mass spec. Details here.
2020/04/01:
Are you interested in structural mass spectrometry, method development, transcription factors or membrane proteins? We are looking for Bc, MSc, PhD students and post-doc! Inquiries should be addressed to Petr Novak.

Downloads

Software for interpretation of high-resolution MS data obtained after protein chemical cross-linking. The software is free to use. If you are using LinX for your research please cite the related publication.

Download here

This software is part of a project that has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 731077P.

HDX-MS related tools for data processing and visualization.
Digestion_metrics - Microsoft Excel macro calculating simple digestion metrics (coverage, average peptide length, redundancy, etc.) Modified supplementary file to publication Kadek A et al Anal Chem. 2014, 86(9):4287-94.
HDXPeptideSplitter - Python script for pre-processing of HDX-MS results before using them in PyMol. Processed data are then loaded through data2bfactor Pymol script written by Robert L. Campbell. This version works with Python version 2.x. For version 3.x and higher use this modified data2bfactor script.