Laboratory of Structural Biology and Cell Signaling

2021/09/23:
Congratulations to Honza (Fiji), now officially PhD in biochemistry!
2021/09/22:
Active and productive collaboration with Sergei Strelkov's lab resulted in another paper on lamin assembly. Work was done under EU_FT-ICR_MS H2020 Project.
2021/09/01:
After several years of post-docking in Hamburg, Alan returns to our lab. Welcome home Alan!
2021/08/20:
Great collaboration with Angel Luis Pey from the University of Granada resulted in a very nice multidisciplinary study on the effect of mutations in human flavoproteins. Now available in Redox Biology! Thanks to EU_FT-ICR_MS H2020 Project for support!
2021/06/15:
We are organizing 2nd Advanced User School under the H2020 EU_FT-ICR_MS consortium. The school will be held in Prague/Vestec, Czech Republic on September 26-30, 2021 and will be stuffed with basics and applications of FT-ICR MS. Participation fee, accommodation and meals covered for 50 selected participants. Registration form can be found HERE. Deadline for application - Aug 23, 2021. Entry to CZ is regulated according to actual COVID situation.
2021/05/31:
Petr's collaboration with the Volf's lab and Austrian's parasitologists is now published in Parasit. Vectors.

2021/07/20:
Call for EPIC-XS proposals is open till Sep 30, 2021. However the pipeline is already quite full, so limited number of proposals can be accepted. Submit via the online submission system.
2021/07/20:
EPIC-XS organizes regular workshops/webinars. The fourht one, on Spatial proteomics, will be on Aug 26, 2021. Check EPIC-XS web site for details.
2021/04/27:
We are looking for post-doc with knowledge of excimer lasers and/or mass spec. Details here.
2020/04/01:
Are you interested in structural mass spectrometry, method development, transcription factors or membrane proteins? We are looking for Bc, MSc, PhD students and post-doc! Inquiries should be addressed to Petr Novak.

Downloads

Software for interpretation of high-resolution MS data obtained after protein chemical cross-linking. The software is free to use. If you are using LinX for your research please cite the related publication.

Download here

This software is part of a project that has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 731077P.

HDX-MS related tools for data processing and visualization.
Digestion_metrics - Microsoft Excel macro calculating simple digestion metrics (coverage, average peptide length, redundancy, etc.) Modified supplementary file to publication Kadek A et al Anal Chem. 2014, 86(9):4287-94.
HDXPeptideSplitter - Python script for pre-processing of HDX-MS results before using them in PyMol. Processed data are then loaded through data2bfactor Pymol script written by Robert L. Campbell. This version works with Python version 2.x. For version 3.x and higher use this modified data2bfactor script.