News:

  • 2025/06/05:

    Great news! 🎉 👏 Ljubi has successfully defended her PhD thesis. Well done, Doctor!

  • 2025/05/29:

    Congratulations to Kuba on successfully defending his master’s thesis! The gate to a PhD is now open!

  • 2025/05/11:

    Well, it took some time, but we’ve finally brought HDX analysis of the Cl⁻/H⁺ antiporter to a high-resolution, high-throughput level, allowing analysis of numerous conditions and pH-matching time points — and the timing couldn’t have been better. Our findings align beautifully with cryo-EM structures from groups at Stanford and offer key insights into the mechanism of chloride/proton transport. The preprint is now live on BioRxiv. Great work, Jasmin and Luky!

  • 2025/05/11:

    That was the first time we started doing fast HDX at low temperature and were locked with Paja in a cold room - cis-PT times. Now the story goes out through a collaborative effort of three groups, led by the Haitin group! Nature *Whatever*, here we come!

  • 2025/04/30:

    Alan's work on coupling a q-TOF mass spectrometer to a synchrotron is now out in Phys. Chem. Chem. Phys.. Check out how protein ions can be dissociated using tools not typically accessible in mass spectrometry.

  • 2025/04/25:

    Get ready to take the next step in your career journey! Join us for the SPIDoc's Career Day, connect with professionals and discover diverse career pathways. When: May 16, 2025. Where: Biocev, CZ or online. See more details in the flyer.

  • 2025/04/16:

    A new paper, led by our current and former students (Valča, Rosi and Michael) shows how combining novel isotopically labeled, MS-cleavable cross-linkers with DIA-MS acquisition improves the description of structural changes in therapeutic proteins.

  • 2025/04/03:

    Great news! Our MSCA Doctoral Network proposal, ProtAIomics, has successfully passed the evaluation stage and is now invited for Grant Agreement Preparation. We look forward to contributing to this pan-European collaboration aimed at making mass spectrometry data interpretation less tedious.

  • 2025/04/01:

    Growing again. New PhD student Marta Cruz 🇵🇹; has already been there for a short stay. Now she returned for several years. Good luck with your PhD project and welcome Marta!

  • 2025/03/31:

    Some fantastic news! Friday, March 28, was a great day for our three PhDs – Marek🎉 👏, Michal🎉 👏, and Lukáš🎉 👏 – as they successfully defended their theses. Congratulations to our new doctors, and thank you for all your work and outstanding presentations!

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Downloads

LinX

  • Software for interpretation of high-resolution MS data obtained after protein chemical cross-linking. The software is free to use. If you are using LinX for your research please cite the related publication.

    Download here

    This software is part of a project that has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 731077P.

HDX tools