Laboratory of Structural Biology and Cell Signaling

2022/11/18:
And yet another one piece (last one in 2022) with Angel Pey and Milagros Medina. Our collaborative effort on NQO1 active site mutations is now in FEBS J. And again thanks EU FT-ICR MS (H2020) for support.
2022/10/13:
This year it looks like a solid harvest of work conducted with Angel L. Pey from Uni of Grenada. Another joint paper, this time on structural effects induced by cavity making mutation on a two domain protein - PGK1. Paper now available in Sci Rep. Thanks EU FT-ICR MS (H2020) for support.
2022/10/10:
Congratulations to Lukas on BIOCEV's PhD Student Publication Award - our JACS paper on FFAP attracts attention 😉. Great collaboration with the Beier group and CF Plus Chemicals. Thanks CSF and H2020 for financial support and HPST for sponsoring this award.
2022/09/13:
Insight into the role of site-specific phosphorylation of human antioxidant and disease-associated flavoprotein NQO1 provided through great collaboration with teams of Angel L. Pey and Milagros Medina. Paper now available in Arch Biochem Biophys. Thanks EU FT-ICR MS (H2020) for support.
2022/09/09:
Congratulations to Bára on succesfull (and very nice) master thesis defense!
2022/08/30:
Nice work with Moshe and Yoni, this time on tweety proteins is finally out. Freely available in Commun. Biol.! Emelia and guys, thanks for great collaboration and thanks EU FT-ICR MS (H2020) for support.

2022/07/22:
Synopsis of Ales' Hippostruct MSCA project is available here.
2022/04/22:
Are you interested in structural mass spectrometry, method development ad/or membrane proteins? We are looking for Bc, MSc, PhD students and post-doc! Inquiries should be addressed to Petr Novak.

Downloads

Software for interpretation of high-resolution MS data obtained after protein chemical cross-linking. The software is free to use. If you are using LinX for your research please cite the related publication.

Download here

This software is part of a project that has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 731077P.

HDX-MS related tools for data processing and visualization.
Digestion_metrics - Microsoft Excel macro calculating simple digestion metrics (coverage, average peptide length, redundancy, etc.) Modified supplementary file to publication Kadek A et al Anal Chem. 2014, 86(9):4287-94.
HDXPeptideSplitter - Python script for pre-processing of HDX-MS results before using them in PyMol. Processed data are then loaded through data2bfactor Pymol script written by Robert L. Campbell. This version works with Python version 2.x. For version 3.x and higher use this modified data2bfactor script.