News:

  • 2026/04/29:

    Maartje moved to another lab some time ago, but we still have things to finish. Published in JASMS, this work expands phase-corrected absorption mode processing for 2D mass spectrometry. This advancement doubles the signal-to-noise ratio and resolving power, significantly improving proteoform sequencing and small-molecule (ergot alkaloid) analysis.

  • 2026/04/27:

    The OP JAK InterMicro project has been instrumental in strengthening intra-institutional collaboration: functional and biophysical assays together with structural mass spectrometry revealed how calcium loading in the acylated segment acts as a molecular switch, controlling the structural folding and membrane penetration capacity of RTX toxins. Now out in J Biol Chem.

  • 2026/04/20:

    Fast, efficient, and online: This recent ACS Omega paper showcases a PNGaseRc-based deglycosylation column that streamlines analysis for therapeutic proteins and antibodies.

  • 2026/04/14:

    Is it time to move past formic acid? In this collaborative study in Anal. Chem., we contributed to establishing propionic acid as a robust alternative for LC-MS. This simple tweak boosts peptide IDs and offers a true “drop-in” way to increase proteome depth without compromising chromatography.

  • 2026/03/25:

    Wrapping up this final piece of research marks a bittersweet milestone. Initiated by our late colleague Angel Luis Pey and led to completion by Milagros Medina, this work reveals new insights into NQO1 function. To your memory, Angel, thank you for the inspiring collaboration.

  • 2026/01/09:

    Fantastic news! Huge dedication and hard work of Jasmin and Luky led to great data on CLC exchange coupling and this fitted perfectly to cryoEM and MD simulations obtained at Stanford by Maduke, Chiu and Dror labs! Joint paper is now out Nat Commun!

  • 2025/12/25:

    Perfect Xmas present 🎄 🎁 for Tomas - his first contribution to a paper and what's even better - it is in the Nat Commun! Collaboration with Roman Sobotka within the Photomachines project.

  • 2025/12/01:

    Great grant news - joint proposal by Ales Hnizda and Alan has been selected for support by the Czech Science Foundation (GACR)! What a continuation of their collaboration, where structural biology meets the clinic.

  • 2025/11/30:

    New Nat Commun paper with the Haitin&Giladi labs is out! Now, with the great molecular dynamics topping from the Giacomello group. Another step towards understanding the mechanism of cis-prenyltrasferases.

  • 2025/10/07:

    Why so quiet in the lab? A big part of peterslab has relocated to Milano 🇮🇹 for the Structural Proteomics Symposium - with 4 talks and 7 posters on the program. Total peterslab invasion. 💥

EC
OPJAK
GACR TACR
BlueSky     Twitter!     YouTube

Important:

Structural characterization of biologicals and membrane proteins - Free EPIC-XS Online Workshop, February 9, 14:45-17:50 CET, 2023

Logo EPIC-XSEU Flag

The European Proteomics Infrastructure Consortium providing Access (EPIC-XS) consists of a unified network of experienced access providers and research groups who share a common goal: to facilitate the development and sustainability of proteomics exploration to all life science researchers within the European Union.

EPIC-XS has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 823839.

Speakers

Topics

  • Structural mass spectrometry
  • Antibody structure
  • Transmembrane proteins
  • Computational approaches

Program

Will be updated but spekaers are confirmed and timing settled

14:45 - 14:55
Participants joining, setting up connection
14:55 - 15:00
Welcome by chairperson, Michael Volny

Session 1 - ANTIBODIES

15:00 - 15:30
Introduction to antibody structure studies by mass spectrometry, Frank Sobott
15:30 - 15:50
Tuning HDX-MS pipeline for antibodies, Petr Man
15:50 - 16:10
Intact and top-down characterization of antibodies by high-resolution native MS, Maurits den Boer
16:10 - 16:20
Q&A with the three speakers moderated by Michael Volny
16:20 - 16:30
Break

Session 2 - TRANSMEMBRANE PROTEINS

16:30 - 17:00
Structural mass spectrometry of membrane proteins, Julian Langer
17:00 - 17:20
Radical labelling techniques applied to membrane proteins, Petr Novak
17:20 - 17:40
Probing the functional dynamics of native membrane proteins by HDX-MS, Argyris Politis
17:40 - 17:50
Q&A with the three speakers moderated by Michael Volny

Registration

The workshop is free but the registration is required. It is available HERE. The session will be hosted on Zoom platform.

The past 2022 EPIC-XS Webinars were a great success; don’t miss the event and join the 10th EPIC-XS Webinar on hot topics (antibodies and membrane proteins) in structural proteomics!

Organizers

  • Petr Novak
  • Petr Man
  • Michael Volny
  • Daniel Kavan