News:

  • 2025/05/11:

    Well, it took some time, but we’ve finally brought HDX analysis of the Cl⁻/H⁺ antiporter to a high-resolution, high-throughput level, allowing analysis of numerous conditions and pH-matching time points — and the timing couldn’t have been better. Our findings align beautifully with cryo-EM structures from groups at Stanford and offer key insights into the mechanism of chloride/proton transport. The preprint is now live on BioRxiv. Great work, Jasmin and Luky!

  • 2025/05/11:

    That was the first time we started doing fast HDX at low temperature and were locked with Paja in a cold room - cis-PT times. Now the story goes out through a collaborative effort of three groups, led by the Haitin group! Nature *Whatever*, here we come!

  • 2025/04/30:

    Alan's work on coupling a q-TOF mass spectrometer to a synchrotron is now out in Phys. Chem. Chem. Phys.. Check out how protein ions can be dissociated using tools not typically accessible in mass spectrometry.

  • 2025/04/25:

    Get ready to take the next step in your career journey! Join us for the SPIDoc's Career Day, connect with professionals and discover diverse career pathways. When: May 16, 2025. Where: Biocev, CZ or online. See more details in the flyer.

  • 2025/04/16:

    A new paper, led by our current and former students (Valča, Rosi and Michael) shows how combining novel isotopically labeled, MS-cleavable cross-linkers with DIA-MS acquisition improves the description of structural changes in therapeutic proteins.

  • 2025/04/03:

    Great news! Our MSCA Doctoral Network proposal, ProtAIomics, has successfully passed the evaluation stage and is now invited for Grant Agreement Preparation. We look forward to contributing to this pan-European collaboration aimed at making mass spectrometry data interpretation less tedious.

  • 2025/04/01:

    Growing again. New PhD student Marta Cruz 🇵🇹; has already been there for a short stay. Now she returned for several years. Good luck with your PhD project and welcome Marta!

  • 2025/03/31:

    Some fantastic news! Friday, March 28, was a great day for our three PhDs – Marek🎉 👏, Michal🎉 👏, and Lukáš🎉 👏 – as they successfully defended their theses. Congratulations to our new doctors, and thank you for all your work and outstanding presentations!

  • 2025/03/31:

    Let’s talk about… well, 💩 . It might not sound pleasant, but our MALDI chip test significantly speeds up the detection of bacteria responsible for severe gut infections—preventing complications that could lead to systemic sepsis. Faster results lead to better treatment and improved patient outcomes.

  • 2025/03/24:

    Great news for barbecue lovers. Say goodbye to worries about botulism poisoning—thanks to our MS-based test that makes Botulinum detection faster and more affordable. This simple method is 100 times quicker, cheaper than the standard approach and, best of all, requires no animal testing!

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Important:

Structural characterization of biologicals and membrane proteins - Free EPIC-XS Online Workshop, February 9, 14:45-17:50 CET, 2023

Logo EPIC-XSEU Flag

The European Proteomics Infrastructure Consortium providing Access (EPIC-XS) consists of a unified network of experienced access providers and research groups who share a common goal: to facilitate the development and sustainability of proteomics exploration to all life science researchers within the European Union.

EPIC-XS has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 823839.

Speakers

Topics

  • Structural mass spectrometry
  • Antibody structure
  • Transmembrane proteins
  • Computational approaches

Program

Will be updated but spekaers are confirmed and timing settled

14:45 - 14:55
Participants joining, setting up connection
14:55 - 15:00
Welcome by chairperson, Michael Volny

Session 1 - ANTIBODIES

15:00 - 15:30
Introduction to antibody structure studies by mass spectrometry, Frank Sobott
15:30 - 15:50
Tuning HDX-MS pipeline for antibodies, Petr Man
15:50 - 16:10
Intact and top-down characterization of antibodies by high-resolution native MS, Maurits den Boer
16:10 - 16:20
Q&A with the three speakers moderated by Michael Volny
16:20 - 16:30
Break

Session 2 - TRANSMEMBRANE PROTEINS

16:30 - 17:00
Structural mass spectrometry of membrane proteins, Julian Langer
17:00 - 17:20
Radical labelling techniques applied to membrane proteins, Petr Novak
17:20 - 17:40
Probing the functional dynamics of native membrane proteins by HDX-MS, Argyris Politis
17:40 - 17:50
Q&A with the three speakers moderated by Michael Volny

Registration

The workshop is free but the registration is required. It is available HERE. The session will be hosted on Zoom platform.

The past 2022 EPIC-XS Webinars were a great success; don’t miss the event and join the 10th EPIC-XS Webinar on hot topics (antibodies and membrane proteins) in structural proteomics!

Organizers

  • Petr Novak
  • Petr Man
  • Michael Volny
  • Daniel Kavan