News:

  • 2026/01/09:

    Fantastic news! Huge dedication and hard work of Jasmin and Luky led to great data on CLC exchange coupling and this fitted perfectly to cryoEM and MD simulations obtained at Stanford by Maduke, Chiu and Dror labs! Joint paper is now out Nat Commun!

  • 2025/12/25:

    Perfect Xmas present 🎄 🎁 for Tomas - his first contribution to a paper and what's even better - it is in the Nat Commun! Collaboration with Roman Sobotka within the Photomachines project.

  • 2025/12/01:

    Great grant news - joint proposal by Ales Hnizda and Alan has been selected for support by the Czech Science Foundation (GACR)! What a continuation of their collaboration, where structural biology meets the clinic.

  • 2025/11/30:

    New Nat Commun paper with the Haitin&Giladi labs is out! Now, with the great molecular dynamics topping from the Giacomello group. Another step towards understanding the mechanism of cis-prenyltrasferases.

  • 2025/10/07:

    Why so quiet in the lab? A big part of peterslab has relocated to Milano 🇮🇹 for the Structural Proteomics Symposium - with 4 talks and 7 posters on the program. Total peterslab invasion. 💥

  • 2025/10/03:

    New paper in N A R ! This project began back in 2020 through the H2020 project EPIC-XS, continued through an Instruct-Internship for Izabella, and kept evolving ever since… now finally reaching its sweet reward. A huge amount of work went into this – experiments capturing fast exchange in poorly structured proteins, and solid proof that DNA “tricks” in HDX-MS really do work. Very happy for Izabella, Dima, Paja, and of course Albane, who led the project.

  • 2025/09/26:

    No more suffering with scripts and macros - interpreting digestion data just got much easier. Our new software DigDig is now released, and the paper is out in Anal. Chem.. To celebrate this, we adopted a DikDik antelope at Prague Zoo - small, agile, and fast, just like our mascot should be. 🐐 Great work of Dan, Zuza and Jasmin!

  • 2025/09/22:

    A big day for Zuzka. Congratulations on nailing the PhD thesis defense 🎉 👏 and becoming a Dogtor🐶!

  • 2025/09/19:

    We just wrapped up an intense and rewarding week at the Structural MS Workshop at BIOCEV. It was a pleasure to work with such enthusiastic participants, and we thank everyone for their energy and contributions. Special thanks go to OP JAK Photomachines and SPIDoc’s MSCA Doctoral Network for funding, to Bruker for software support, and to CIISB Instruct-CZ for access to instrumentation.

  • 2025/08/11:

    Biophysics, HDX-MS and statistical modelling on track of antibiotic sequestration now out in ACS Bio Med Chem Au. Great collaboration with Athi N. Naganathan.

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Important:

Structural characterization of biologicals and membrane proteins - Free EPIC-XS Online Workshop, February 9, 14:45-17:50 CET, 2023

Logo EPIC-XSEU Flag

The European Proteomics Infrastructure Consortium providing Access (EPIC-XS) consists of a unified network of experienced access providers and research groups who share a common goal: to facilitate the development and sustainability of proteomics exploration to all life science researchers within the European Union.

EPIC-XS has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 823839.

Speakers

Topics

  • Structural mass spectrometry
  • Antibody structure
  • Transmembrane proteins
  • Computational approaches

Program

Will be updated but spekaers are confirmed and timing settled

14:45 - 14:55
Participants joining, setting up connection
14:55 - 15:00
Welcome by chairperson, Michael Volny

Session 1 - ANTIBODIES

15:00 - 15:30
Introduction to antibody structure studies by mass spectrometry, Frank Sobott
15:30 - 15:50
Tuning HDX-MS pipeline for antibodies, Petr Man
15:50 - 16:10
Intact and top-down characterization of antibodies by high-resolution native MS, Maurits den Boer
16:10 - 16:20
Q&A with the three speakers moderated by Michael Volny
16:20 - 16:30
Break

Session 2 - TRANSMEMBRANE PROTEINS

16:30 - 17:00
Structural mass spectrometry of membrane proteins, Julian Langer
17:00 - 17:20
Radical labelling techniques applied to membrane proteins, Petr Novak
17:20 - 17:40
Probing the functional dynamics of native membrane proteins by HDX-MS, Argyris Politis
17:40 - 17:50
Q&A with the three speakers moderated by Michael Volny

Registration

The workshop is free but the registration is required. It is available HERE. The session will be hosted on Zoom platform.

The past 2022 EPIC-XS Webinars were a great success; don’t miss the event and join the 10th EPIC-XS Webinar on hot topics (antibodies and membrane proteins) in structural proteomics!

Organizers

  • Petr Novak
  • Petr Man
  • Michael Volny
  • Daniel Kavan