News:

  • 2025/10/07:

    Why so quiet in the lab? A big part of peterslab has relocated to Milano 🇮🇹 for the Structural Proteomics Symposium - with 4 talks and 7 posters on the program. Total peterslab invasion. 💥

  • 2025/10/03:

    New paper in N A R ! This project began back in 2020 through the H2020 project EPIC-XS, continued through an Instruct-Internship for Izabella, and kept evolving ever since… now finally reaching its sweet reward. A huge amount of work went into this – experiments capturing fast exchange in poorly structured proteins, and solid proof that DNA “tricks” in HDX-MS really do work. Very happy for Izabella, Dima, Paja, and of course Albane, who led the project.

  • 2025/09/26:

    No more suffering with scripts and macros - interpreting digestion data just got much easier. Our new software DigDig is now released, and the paper is out in Anal. Chem.. To celebrate this, we adopted a DikDik antelope at Prague Zoo - small, agile, and fast, just like our mascot should be. 🐐 Great work of Dan, Zuza and Jasmin!

  • 2025/09/22:

    A big day for Zuzka. Congratulations on nailing the PhD thesis defense 🎉 👏 and becoming a Dogtor🐶!

  • 2025/09/19:

    We just wrapped up an intense and rewarding week at the Structural MS Workshop at BIOCEV. It was a pleasure to work with such enthusiastic participants, and we thank everyone for their energy and contributions. Special thanks go to OP JAK Photomachines and SPIDoc’s MSCA Doctoral Network for funding, to Bruker for software support, and to CIISB Instruct-CZ for access to instrumentation.

  • 2025/08/11:

    Biophysics, HDX-MS and statistical modelling on track of antibiotic sequestration now out in ACS Bio Med Chem Au. Great collaboration with Athi N. Naganathan.

  • 2025/07/07:

    Great and fruitful collaboration with the Haitin group, this time on GGPPS (aka "another prenyl transferase"). Inspiring work on enzyme oligomerization using HDX and native MS. And a second PhD paper for Jasmin! 🎉

  • 2025/06/25:

    Congrats to Pepa 🎉 👏 on a successful PhD defense. Good luck in your furture steps Pepa and thanks for all the fun!

  • 2025/06/25:

    We are organizing a hands-on Structural MS workshop supported by the OP JAK – Photomachines project and the SPIDoc's doctoral network. This is a unique opportunity to learn sample preparation, analysis, and data processing in HDX-MS, native MS, top-down MS, and cross-linking MS - topped off with a touch of ultra-high-resolution mass spectrometry! Don’t miss your chance to register. The workshop will take place on September 15–19, 2025, at BIOCEV.

  • 2025/06/05:

    Great news! 🎉 👏 Ljubi has successfully defended her PhD thesis. Well done, Doctor!

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Important:

Software

You can find thecollection of software tools created in our laboratory:

  • DeutEx

    Application for evaluating of HDX/MS experiments.

    DeutEx is now licensed to Bruker and we will work together on further development.

  • DigDig

    DigDig, a standalone, Java-based software tool for evaluating and comparing proteolytic digestion across diverse experimental conditions.

    To obtain a copy of DigDig visit its dedicated webpage. You can also jump straight to the documentation.

  • LinX

    Software for interpretation of high-resolution MS data obtained after protein chemical cross-linking. The software is free to use. If you are using LinX for your research please cite the related publication.

    Download here

    This software is part of a project that has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 731077P.

  • MSTools

    Web based application for visualization and presentation of HXMS data. Learn more about this set of tools in IJMS.

    To use MSTools, visit its section on our website.

  • HDX tools