Laboratory of Structural Biology and Cell Signaling

2019/06/24:
Few years ago, we helped Petrak's lab with the development of transmembrane proteome analysis. We are happy that Jirka's team is pushing it further and even happier we still keep in touch as this resulted in another nice J Proteomics paper.
2019/06/12:
Congratulations to our Bc students (Zuzka, Verča, Týna, Kamila and Jana) on successful defense of their Bc theses.
2019/05/31:
Congratulations to Lucka Wallenfels (Hernychová) on successful defense of her PhD thesis and other happy life events. All the best in the future Lucka!.
2019/05/06:
Attempts to fully uderstand and somehow unify chemical cross-linking pushed further through interlaboratory comparion in which we participated. Read more in this community-wide Analytical Chemistry paper.
2019/04/29:
New publication about oligomerisation of NK cell receptors evaluated using homo-FRET and high resolution mass spectrometry - colaboration with Marek Cebecauer's group - is online in the International Journal of Molecular Sciences.
2019/01/26:
Joint paper with Ales Hnizda on structural characterization of pyrophosphatase NUDT15 and its thiopurine intolerance causing mutations is now available in Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics.

2019/01/10:
We are part of another Horizon 2020 project EPIC-XS (reg. no 823839) focused on the cutting edge proteomic techniques. This project provides Trans-National Access and also focuses on the development of the techniques.
2018/01/03:
Our lab is a part of Horizon 2020 project EU FT-ICR MS (reg. no 731077). Through this project you can access our expertise as well as other participating FT-ICR labs. Check Trans-National Acess web section for more details. Also, various FT-ICR focused courses and schools are organized by the labs participating in the project.
2017/12/20:
Bachelor and master theses are available in the lab. Areas of structrual biology, cutting edge mass spectrometry and cell signalling are awaiting new students. Check the tab Teaching.

Výuka

Produkce a purifikace proteinu s využitím pro hmotnostní spektrometrii
školitel: Daniel Kavan
Počítačové zpracování dat z hmotnostní spektrometrie.
školitel: Daniel Kavan

Optimalizace chemického sítění proteinu s nukleovou kyselinou.
školitel: Petr Novák
Příprava afinitních nosičů pro klinickou diagnostiku.
školitel: Petr Pompach
Validace biologických terapeutik radikálovým značením proteinů.
školitel: Zdeněk Kukačka