Laboratory of Structural Biology and Cell Signaling

2019/08/05:
5th Short Course on FT-ICR-MS aimed at "Basics of FT-ICR: dynamic harmonization and computer simulation" will be held in early October in Moscow. Apply now, no participation fee, accommodation and meals covered!
2019/07/24:
Preprint version of our paper combining structural MS approaches for characterization of transcription factor / DNA interaction is now available in Biomolecules.
2019/07/19:
Chromatin Proteomics Workshop coorganized by EPIC-XS H2020 consortium will be on Sep 22-27, 2019 in Greece. Deadline (Jul 29) is approaching!.
2019/07/15:
Two new papers dealing with HDX-MS are out. In one we contributed to very important community wide guidelines paper in Nat. Methods - Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments. Antoher one is a joint Anal. Chem. paper with Kasper Rand's lab on HDX-compatible digestion of membrane proteins.
2019/07/10:
Joint paper with Valasek's lab describing how chemical cross-linking helps in structural characterization of 40S ribosomal subunit interacting with eIFs is now available in Nucleic Acid Research.
2019/07/10:
Short course on High Resolution Tandem Mass Spectrometry of Biomolecules will be organized by the EU_FT-ICR_MS H2020 consortium. Save the date and place: Aug 21-23, 2019, Warwick. Register here.

2019/08/15:
Do you want to analyze your samples at some top European proteomics lab? Apply for the access within the EPIC-XS consortium. Second round of submissions closes on Sep 30, 2019.
2019/03/27:
We are part of another Horizon 2020 project EPIC-XS (reg. no 823839) focused on the cutting edge proteomic techniques. This project provides Trans-National Access and also focuses on the development of the techniques.
2018/01/03:
Our lab is a part of Horizon 2020 project EU FT-ICR MS (reg. no 731077). Through this project you can access our expertise as well as other participating FT-ICR labs. Check Trans-National Acess web section for more details. Also, various FT-ICR focused courses and schools are organized by the labs participating in the project.
2017/12/20:
Bachelor and master theses are available in the lab. Areas of structrual biology, cutting edge mass spectrometry and cell signalling are awaiting new students. Check the tab Teaching.

Výuka

Produkce a purifikace proteinu s využitím pro hmotnostní spektrometrii
školitel: Daniel Kavan
Počítačové zpracování dat z hmotnostní spektrometrie.
školitel: Daniel Kavan

Optimalizace chemického sítění proteinu s nukleovou kyselinou.
školitel: Petr Novák
Příprava afinitních nosičů pro klinickou diagnostiku.
školitel: Petr Pompach
Validace biologických terapeutik radikálovým značením proteinů.
školitel: Zdeněk Kukačka