Laboratory of Structural Biology and Cell Signaling

2021/03/08:
Our software LinX for interpretation of chemical cross-linking data, with special features for homodimer elucidation or protein:DNA cross-links is now available on GitHub and related paper published in J Prot Res
2021/02/05:
Nice colaboration with Erik Sedlak's group on cytochrome c oxidation is now available in Int J Biol Macromol. Thanks EU_FT-ICR_MS H2020 Project for supporting this trans-national access! Enjoy 50 days of free access using the link above (till Mar 27, 2021).
2021/01/31:
New joint paper with Ales, from the times he was not part of our lab. FEBS J paper on Ku70/80 intramolecular interactions combining cryoEM and structural MS.
2021/01/08:
Collaboration with the Ludwig lab resulted in another paper on wood degrading enzymes. This time about chimeric CDHs in ACS Catalysis.
2020/12/18:
Paper on TEAD1-DNA interaction is now published in Structure. Enjoy 50 days of free access (till Feb 4, 2021).
2020/12/14:
Congratulations to Paja, now officially PhD in biochemistry!

2021/03/15:
EPIC-XS organizes regular workshops/webinars. The second one, on Computational proteomics, will be on Apr 29, 2021. Check EPIC-XS web site for details.
2021/02/03:
Call for EPIC-XS proposals is open till March 31, 2021. Next round will be till Mar 31, 2021! Submit via the online submission system.
2020/07/15:
Visitors coming to our lab from abroad should consult the web page of the Czech Ministry of Health regarding COVID-19 related travel restrictions.
2020/06/02:
We are looking for post-doc and PhD to join our team and work on various projects using structural mass spectrometry! Inquiries should be addressed to Petr Novak.
2019/03/27:
We are part of another Horizon 2020 project EPIC-XS (reg. no 823839) focused on the cutting edge proteomic techniques. This project provides Trans-National Access and also focuses on the development of the techniques.
2018/01/03:
Our lab is a part of Horizon 2020 project EU FT-ICR MS (reg. no 731077). Through this project you can access our expertise as well as other participating FT-ICR labs. Check Trans-National Acess web section for more details. Also, various FT-ICR focused courses and schools are organized by the labs participating in the project.
2017/12/20:
Bachelor and master theses are available in the lab. Areas of structrual biology, cutting edge mass spectrometry and cell signalling are awaiting new students. Check the tab Teaching.

Výuka

Produkce a purifikace proteinu s využitím pro hmotnostní spektrometrii
školitel: Daniel Kavan
Počítačové zpracování dat z hmotnostní spektrometrie.
školitel: Daniel Kavan

Optimalizace chemického sítění proteinu s nukleovou kyselinou.
školitel: Petr Novák
Příprava afinitních nosičů pro klinickou diagnostiku.
školitel: Petr Pompach
Validace biologických terapeutik radikálovým značením proteinů.
školitel: Zdeněk Kukačka