Laboratory of Structural Biology and Cell Signaling

2020/06/29:
We are organizing 7th Short Course Structural Proteomics: Analysis of protein surface accessibility by Top Down mass spectrometry under the H2020 EU_FT-ICR_MS consortium. The course will be held in Prague/Vestec, Czech Republic on August 16-19, 2020. There are still free places so do not hesitate to apply. Please be aware that travel restriction may apply and the situation may change till half of August.
2020/06/18:
Nice work and pleasant collaboration with the Haitin Lab on soluble chloride channel Clic-5 now out in The FASEB J.
Thanks EU_FT-ICR_MS H2020 Project for support!
2020/06/12:
Another collaborative work with Haitin Lab done under EU_FT-ICR_MS H2020 Project this time on cis-prenyltrasferase is available as preprint on bioRXiv.
2020/06/01:
Ales Hnizda joined our lab. He is funded by Marie Sklodowska-Curie Action Individual Fellowship (Widening). Welcome Ales!
2020/05/05:
Collaboration with RECAMO team on heat shock proteins and co-chaperones resulted in another paper The interaction of the mitochondrial protein importer TOMM34 with HSP70 is regulated by TOMM34 phosphorylation and binding to 14-3-3 adaptors. which is now available in J Biol Chem.
2020/05/03:
New review Targeting ERK-Hippo Interplay in Cancer Therapy. from Karel is now published in Int. J. Mol. Sci..

2020/06/24:
Visitors coming to our lab from abroad should consult the web page of the Czech Ministry of Health regarding COVID-19 related travel restrictions.
2020/06/18:
Call for EPIC-XS proposals is open till June 30, 2020. Next round will be till Sep 30, 2020! Submit via the online submission system.
2020/06/02:
We are looking for post-doc and PhD to join our team and work on various projects using structural mass spectrometry! Inquiries should be addressed to Petr Novak.
2019/03/27:
We are part of another Horizon 2020 project EPIC-XS (reg. no 823839) focused on the cutting edge proteomic techniques. This project provides Trans-National Access and also focuses on the development of the techniques.
2018/01/03:
Our lab is a part of Horizon 2020 project EU FT-ICR MS (reg. no 731077). Through this project you can access our expertise as well as other participating FT-ICR labs. Check Trans-National Acess web section for more details. Also, various FT-ICR focused courses and schools are organized by the labs participating in the project.
2017/12/20:
Bachelor and master theses are available in the lab. Areas of structrual biology, cutting edge mass spectrometry and cell signalling are awaiting new students. Check the tab Teaching.

Výuka

Produkce a purifikace proteinu s využitím pro hmotnostní spektrometrii
školitel: Daniel Kavan
Počítačové zpracování dat z hmotnostní spektrometrie.
školitel: Daniel Kavan

Optimalizace chemického sítění proteinu s nukleovou kyselinou.
školitel: Petr Novák
Příprava afinitních nosičů pro klinickou diagnostiku.
školitel: Petr Pompach
Validace biologických terapeutik radikálovým značením proteinů.
školitel: Zdeněk Kukačka