News:

  • 2021/03/08:

    Our software LinX for interpretation of chemical cross-linking data, with special features for homodimer elucidation or protein:DNA cross-links is now available on GitHub and related paper published in J Prot Res

  • 2021/02/05:

    Nice colaboration with Erik Sedlak's group on cytochrome c oxidation is now available in Int J Biol Macromol. Thanks EU_FT-ICR_MS H2020 Project for supporting this trans-national access! Enjoy 50 days of free access using the link above (till Mar 27, 2021).

  • 2021/01/31:

    New joint paper with Ales, from the times he was not part of our lab. FEBS J paper on Ku70/80 intramolecular interactions combining cryoEM and structural MS.

  • 2021/01/08:

    Collaboration with the Ludwig lab resulted in another paper on wood degrading enzymes. This time about chimeric CDHs in ACS Catalysis.

  • 2020/12/18:

    Paper on TEAD1-DNA interaction is now published in Structure. Enjoy 50 days of free access (till Feb 4, 2021).

  • 2020/12/14:

    Congratulations to Paja, now officially PhD in biochemistry!

Horizon 2020
EPIC-XS
EU FT-ICR MS MSCA

Important:

  • 2021/03/15:

    EPIC-XS organizes regular workshops/webinars. The second one, on Computational proteomics, will be on Apr 29, 2021. Check EPIC-XS web site for details.

  • 2021/02/03:

    Call for EPIC-XS proposals is open till March 31, 2021. Next round will be till Mar 31, 2021! Submit via the online submission system.

  • 2020/07/15:

    Visitors coming to our lab from abroad should consult the web page of the Czech Ministry of Health regarding COVID-19 related travel restrictions.

  • 2020/06/02:

    We are looking for post-doc and PhD to join our team and work on various projects using structural mass spectrometry! Inquiries should be addressed to Petr Novak.

  • 2019/03/27:

    We are part of another Horizon 2020 project EPIC-XS (reg. no 823839) focused on the cutting edge proteomic techniques. This project provides Trans-National Access and also focuses on the development of the techniques.

  • 2018/01/03:

    Our lab is a part of Horizon 2020 project EU FT-ICR MS (reg. no 731077). Through this project you can access our expertise as well as other participating FT-ICR labs. Check Trans-National Acess web section for more details. Also, various FT-ICR focused courses and schools are organized by the labs participating in the project.

  • 2017/12/20:

    Bachelor and master theses are available in the lab. Areas of structrual biology, cutting edge mass spectrometry and cell signalling are awaiting new students. Check the tab Teaching.

Výuka

Volná témata bakalářských a diplomových prací

Diplomové práce

  • Produkce a purifikace proteinu s využitím pro hmotnostní spektrometrii
    školitel: Daniel Kavan

  • Počítačové zpracování dat z hmotnostní spektrometrie.
    školitel: Daniel Kavan

Bakalářské práce

  • Optimalizace chemického sítění proteinu s nukleovou kyselinou.
    školitel: Petr Novák

  • Příprava afinitních nosičů pro klinickou diagnostiku.
    školitel: Petr Pompach

  • Validace biologických terapeutik radikálovým značením proteinů.
    školitel: Zdeněk Kukačka

Výuka – Katedra Biochemie, Přírodovědecká fakulta, Univerzita Karlova