Laboratory of Structural Biology and Cell Signaling

News:

2025/12/01:
Great grant news - joint proposal by Ales Hnizda and Alan has been selected for support by the Czech Science Foundation (GACR)! What a continuation of their collaboration, where structural biology meets the clinic.
2025/11/30:
New Nat Commun paper with the Haitin&Giladi labs is out! Now, with the great molecular dynamics topping from the Giacomello group. Another step towards understanding the mechanism of cis-prenyltrasferases.
2025/10/07:
Why so quiet in the lab? A big part of peterslab has relocated to Milano 🇮🇹 for the Structural Proteomics Symposium - with 4 talks and 7 posters on the program. Total peterslab invasion. 💥
2025/10/03:
New paper in N A R ! This project began back in 2020 through the H2020 project EPIC-XS, continued through an Instruct-Internship for Izabella, and kept evolving ever since… now finally reaching its sweet reward. A huge amount of work went into this – experiments capturing fast exchange in poorly structured proteins, and solid proof that DNA “tricks” in HDX-MS really do work. Very happy for Izabella, Dima, Paja, and of course Albane, who led the project.
2025/09/26:
No more suffering with scripts and macros - interpreting digestion data just got much easier. Our new software DigDig is now released, and the paper is out in Anal. Chem.. To celebrate this, we adopted a DikDik antelope at Prague Zoo - small, agile, and fast, just like our mascot should be. 🐐 Great work of Dan, Zuza and Jasmin!
2025/09/22:
A big day for Zuzka. Congratulations on nailing the PhD thesis defense 🎉 👏 and becoming a Dogtor🐶!
2025/09/19:
We just wrapped up an intense and rewarding week at the Structural MS Workshop at BIOCEV. It was a pleasure to work with such enthusiastic participants, and we thank everyone for their energy and contributions. Special thanks go to OP JAK Photomachines and SPIDoc’s MSCA Doctoral Network for funding, to Bruker for software support, and to CIISB Instruct-CZ for access to instrumentation.
2025/08/11:
Biophysics, HDX-MS and statistical modelling on track of antibiotic sequestration now out in ACS Bio Med Chem Au. Great collaboration with Athi N. Naganathan.
2025/07/07:
Great and fruitful collaboration with the Haitin group, this time on GGPPS (aka "another prenyl transferase"). Inspiring work on enzyme oligomerization using HDX and native MS. And a second PhD paper for Jasmin! 🎉
2025/06/25:
Congrats to Pepa 🎉 👏 on a successful PhD defense. Good luck in your furture steps Pepa and thanks for all the fun!

Important:

2025/10/01:
Our new software tool DigDig is now available! Download it here, explore the wiki with tutorials and data and the Anal. Chem. paper.
2025/04/25:
Our DeutEx program was licensed to Bruker!
2024/04/05:
You can meet/follow us at BlueSky, X (Twitter) and we even have a YouTube channel!
2022/07/22:
Synopsis of Ales' Hippostruct MSCA project is available here.