News:

  • 2019/05/06:

    Attempts to fully uderstand and somehow unify chemical cross-linking pushed further through interlaboratory comparion in which we participated. Read more in this community-wide Analytical Chemistry paper.

  • 2019/04/29:

    New publication about oligomerisation of NK cell receptors evaluated using homo-FRET and high resolution mass spectrometry - colaboration with Marek Cebecauer's group - is online in the International Journal of Molecular Sciences.

  • 2019/01/26:

    Joint paper with Ales Hnizda on structural characterization of pyrophosphatase NUDT15 and its thiopurine intolerance causing mutations is now available in Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics.

  • 2018/11/28:

    We recieved funding from Czech Science Foundation to study protein structure by reactive radical footprinting and top-down mass spectrometry.

Important:

  • 2019/04/29:

    We are part of another Horizon 2020 project EPIC-XS (reg. no 823839) focused on the cutting edge proteomic techniques. This project provides Trans-National Access and also focuses on the development of the techniques.

  • 2018/07/13:

    Our lab is a part of Horizon 2020 project EU FT-ICR MS (reg. no 731077). Through this project you can access our expertise as well as other participating FT-ICR labs. Check Trans-National Acess web section for more details. Also, various FT-ICR focused courses and schools are organized by the labs participating in the project.

  • 2018/06/25:

    Bachelor and master theses are available in the lab. Areas of structrual biology, cutting edge mass spectrometry and cell signalling are awaiting new students. Check the tab Teaching.

About laboratory

Laboratory of Structural Biology and Cell Signaling consists of a multidisciplinary team whose thematic focus is divided into two main directions. Structural biology group produces proteins by recombinant expression technologies and characterizes the protein or protein-ligand structures and their dynamics utilizing advanced mass spectrometric techniques. Cell signaling unit examines the linkages of cellular signaling to the metabolism of cancer cells using molecular biology and biochemistry methods. Through the collaboration of the two groups a unique research platform is formed, wherein the results obtained by the study of biological systems can also be verified and explained at the molecular level. Laboratory is located at the BIOCEV center in Vestec.

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