News:

  • 2017/12/28:

    The effect of Quambalarine B on leukemic cells is now published in Oncotarget.

  • 2017/12/18:

    Software LinX ready for download.

  • 2017/12/15:

    A paper about structure of beta-N-acetylhexosaminidase is now in FEBS J.

  • 2017/12/14:

    Our work describing influence of cross-linker on the protein structure is now in Analytical Chemistry (2017/12/14)

  • 2017/11/03:

    Paper about structure and dynamics of heme-containing gas sensing protein where three groups joint their expertise (Martinkova lab, Dohnalek lab and our group) has just been accepted in J Biol Chem (2017/11/01)

  • 2017/11/03:

    Three talks and five posters from the lab just presented at the 7th Symposium on Structural Biology which was again a great event! (2017/10/25)

Important:

  • 2017/11/08:

    Several bachelor and master theses are available in the lab. Areas of structrual biology, cutting edge mass spectrometry and cell signalling are awaiting new students. Check the tab Teaching.

About laboratory

Laboratory of Structural Biology and Cell Signaling consists of a multidisciplinary team whose thematic focus is divided into two main directions. Structural biology group produces proteins by recombinant expression technologies and characterizes the protein or protein-ligand structures and their dynamics utilizing advanced mass spectrometric techniques. Cell signaling unit examines the linkages of cellular signaling to the metabolism of cancer cells using molecular biology and biochemistry methods. Through the collaboration of the two groups a unique research platform is formed, wherein the results obtained by the study of biological systems can also be verified and explained at the molecular level.

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