News:

  • 2020/03/26:

    CIISB offers priority and free-of-charge access for COVID-19 research proposals! More here

  • 2020/03/05:

    Cellulose degradation combo by Franta. Two papers arising from collaboration with Roland Ludwig and Daniel Kracher are out. One in Biomolecules and another in Biotechol. Biofuels.

  • 2020/03/05:

    Another TNA access under EU_FT-ICR_MS H2020 Project resulted in joint paper with Erik Sedlak from Kosice. Now published in Scientific Reports.

  • 2020/03/03:

    Dmitry Loginov joined our lab. Welcome Dmitry!

  • 2020/02/28:

    Our systematic effort to understand what is going in chemical cross-linking resulted in another paper. This time about the cross-linker polarity. Enjoy author's copy available for 50 days.

  • 2020/01/23:

    Collaboration with Obsil's team on the interaction between 14-3-3 and caspase-2 was accepted in FEBS J.

Horizon 2020
EPIC-XS
EU FT-ICR MS

Important:

  • 2020/01/07:

    Call for EPIC-XS proposals was closed on Dec 31, 2019. Get ready for next round which closes on March 31, 2020! Submit via the online submission system.

  • 2019/11/12:

    We are looking for post-doc and PhD to join our team and work on various projects using structural mass spectrometry! Inquiries should be addressed to Petr Novak.

  • 2019/03/27:

    We are part of another Horizon 2020 project EPIC-XS (reg. no 823839) focused on the cutting edge proteomic techniques. This project provides Trans-National Access and also focuses on the development of the techniques.

  • 2018/01/03:

    Our lab is a part of Horizon 2020 project EU FT-ICR MS (reg. no 731077). Through this project you can access our expertise as well as other participating FT-ICR labs. Check Trans-National Acess web section for more details. Also, various FT-ICR focused courses and schools are organized by the labs participating in the project.

  • 2017/12/20:

    Bachelor and master theses are available in the lab. Areas of structrual biology, cutting edge mass spectrometry and cell signalling are awaiting new students. Check the tab Teaching.

About laboratory



Laboratory of Structural Biology and Cell Signaling consists of a multidisciplinary team whose thematic focus is divided into two main directions. Structural biology group produces proteins by recombinant expression technologies and characterizes the protein or protein-ligand structures and their dynamics utilizing advanced mass spectrometric techniques. Cell signaling unit examines the linkages of cellular signaling to the metabolism of cancer cells using molecular biology and biochemistry methods. Through the collaboration of the two groups a unique research platform is formed, wherein the results obtained by the study of biological systems can also be verified and explained at the molecular level. Laboratory is located at the BIOCEV center in Vestec.

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