News:

  • 2023/05/15:

    Congratulations to Terka on the best IMIC master thesis in 2022!

  • 2023/05/15:

    MALDI chips rocks! Pepa's first paper is out in Clinical Proteomics!

  • 2023/04/13:

    Thrilling collaboration with Klara Hlouchova on “non-existing proteins”. Our achievements got well accepted in Nat Ecol Evol. Thanks EPIC-XS for support.

  • 2023/04/12:

    And yet another one piece with Angel Pey and Milagros Medina. Our collaborative effort on NQO1 active site mutations is now fully published in FEBS J. And again thanks EU FT-ICR MS (H2020) for support.

  • 2022/10/13:

    This year it looks like a solid harvest of work conducted with Angel L. Pey from Uni of Grenada. Another joint paper, this time on structural effects induced by cavity making mutation on a two domain protein - PGK1. Paper now available in Sci Rep. Thanks EU FT-ICR MS (H2020) for support.

  • 2022/10/10:

    Congratulations to Lukas on BIOCEV's PhD Student Publication Award - our JACS paper on FFAP attracts attention 😉. Great collaboration with the Beier group and CF Plus Chemicals. Thanks CSF and H2020 for financial support and HPST for sponsoring this award.

  • 2022/09/13:

    Insight into the role of site-specific phosphorylation of human antioxidant and disease-associated flavoprotein NQO1 provided through great collaboration with teams of Angel L. Pey and Milagros Medina. Paper now available in Arch Biochem Biophys. Thanks EU FT-ICR MS (H2020) for support.

  • 2022/09/09:

    Congratulations to Bára on succesfull (and very nice) master thesis defense!

  • 2022/08/30:

    Nice work with Moshe and Yoni, this time on tweety proteins is finally out. Freely available in Commun. Biol.! Emelia and guys, thanks for great collaboration and thanks EU FT-ICR MS (H2020) for support.

  • 2022/07/21:

    Our work on top-down FPOP, highlighting the benefits of exact gas-phase isolation of selected protein species and multiple fragmentation modes, is now available in the Analytical Chemistry!

Horizon 2020
EPIC-XS
EU FT-ICR MS MSCA

Important:

  • 2023/02/20:

    We are looking for java programmer. Position for two years. Collaboration with industrial partner - Bruker Daltonics! More details HERE.

  • 2022/07/22:

    Synopsis of Ales' Hippostruct MSCA project is available here.

  • 2022/04/22:

    Are you interested in structural mass spectrometry, method development ad/or membrane proteins? We are looking for Bc, MSc, PhD students and post-doc! Inquiries should be addressed to Petr Novak.

About laboratory



Laboratory of Structural Biology and Cell Signaling consists of a multidisciplinary team whose thematic focus is divided into two main directions. Structural biology group produces proteins by recombinant expression technologies and characterizes the protein or protein-ligand structures and their dynamics utilizing advanced mass spectrometric techniques. Cell signaling unit examines the linkages of cellular signaling to the metabolism of cancer cells using molecular biology and biochemistry methods. Through the collaboration of the two groups a unique research platform is formed, wherein the results obtained by the study of biological systems can also be verified and explained at the molecular level. Laboratory is located at the BIOCEV center in Vestec.

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