News:

  • 2025/04/01:

    Growing again. New PhD student Marta Cruz 🇵🇹; has already been there for a short stay. Now she returned for several years. Good luck with your PhD project and welcome Marta!

  • 2025/02/24:

    It’s official – Bruker has licensed our DeutEx software! This means faster HDX data processing is now available to users of timsTOFs, qTOFs, and FT-ICRs (MRMS). We're excited to bring DeutEx to more researchers through this collaboration.

  • 2025/02/10:

    Another step towards understanding protein folding and enzyme catalysis in crucial NQO1 redox flavoenzyme. Collaboration with Angel L. Pey (Granada) and Milagros Medina (Zaragoza) ready to go out. For now at least on BioRXiv.

  • 2025/02/03:

    Canadians 🇨🇦 are now making the second largest minority in the lab. Just for a while but we are happy to have May here. Welcome May Constabel from the MS-SPIDOC consortium. May will work with Alan and Ezgi on laser-armed 💥 big magnet 🧲.

  • 2025/02/01:

    Andrew R.M. Michael 🇨🇦 is joinig us as a postdoc after completing his PhD in Canada on in vivo protein cross-linking MS. Big welcome to Andrew!

  • 2024/12/20:

    Last paper of 2024 out. Alex turned the theoretical part of his diploma thesis into a review on HSPs in Folia Biologica.

  • 2024/11/27:

    Totally unexpected but we found a new cleavage preference in proteases cleaving primarily after proline (so-called PPCEs). These enzymes chew not only after Pro and Ala but also reduced Cys! Rewrite the textbooks! Also, this is the awaited first author paper of Zuza and the very first paper for Jasmin.

  • 2024/09/26:

    New group members! Welcome Ezgi 🇹🇷 , Sascha 🇷🇸, Tomas. Also and some "old" ones starting their PhD (Jasmina and Michael)! Great to have you here!

  • 2024/09/26:

    Congratulations to Luky on completing the PhD Quest !🎉 👏Dr. Fojtik is now ready for his Sotio adventures. Good luck!

  • 2024/08/16:

    Our expertise in analyzing products of protein oxidation may help other research teams. Glad, we got just the enzyme and were not involved in the fight with termites.

Horizon 2020
EPIC-XS
EU FT-ICR MS MSCA

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About laboratory



Laboratory of Structural Biology and Cell Signaling consists of a multidisciplinary team whose thematic focus is divided into two main directions. Structural biology group produces proteins by recombinant expression technologies and characterizes the protein or protein-ligand structures and their dynamics utilizing advanced mass spectrometric techniques. Cell signaling unit examines the linkages of cellular signaling to the metabolism of cancer cells using molecular biology and biochemistry methods. Through the collaboration of the two groups a unique research platform is formed, wherein the results obtained by the study of biological systems can also be verified and explained at the molecular level. Laboratory is located at the BIOCEV center in Vestec.

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