News:

  • 2021/04/21:

    Proteomic analysis of F. pinicola secretome leading to expression and characterization of two laccases (collaboration with the Ludwig Lab) has just been accepted in Enzyme Microb Technol

  • 2021/04/09:

    Structural analysis of human haptoglobin by FPOP and the benefits of ion mobility (TIMS/PASEF) for such analysis is now published in ACS Omega

  • 2021/03/25:

    Structural aspects of Von Willebrand factor binding and processing by metallopeptidase ADAMTS-13 studiedby integrative structural biology. Trans-national access via the EPIC-XS resulted in a joint publication in J. Mol. Biol.

  • 2021/03/10:

    The results of collaboration with the parasitology groups from Charles University and Morroco are now published in Transboundary and Emerging Diseases

  • 2021/03/08:

    Our software LinX for interpretation of chemical cross-linking data, with special features for homodimer elucidation or protein:DNA cross-links is now available on GitHub and related paper published in J Prot Res

  • 2021/02/05:

    Nice colaboration with Erik Sedlak's group on cytochrome c oxidation is now available in Int J Biol Macromol. Thanks EU_FT-ICR_MS H2020 Project for supporting this trans-national access! Enjoy 50 days of free access using the link above (till Mar 27, 2021).

Horizon 2020
EPIC-XS
EU FT-ICR MS MSCA

Important:

  • 2021/05/10:

    EPIC-XS organizes regular workshops/webinars. The third one, on Clinical proteomics, will be on June 17, 2021. Check EPIC-XS web site for details.

  • 2021/04/27:

    We are looking for post-doc with knowledge of excimer lasers and/or mass spec. Details here.

  • 2021/04/27:

    Call for EPIC-XS proposals is open till June 30, 2021. Next round will be till Sep 30, 2021! Submit via the online submission system.

  • 2020/04/01:

    Are you interested in structural mass spectrometry, method development, transcription factors or membrane proteins? We are looking for Bc, MSc, PhD students and post-doc! Inquiries should be addressed to Petr Novak.

About laboratory



Laboratory of Structural Biology and Cell Signaling consists of a multidisciplinary team whose thematic focus is divided into two main directions. Structural biology group produces proteins by recombinant expression technologies and characterizes the protein or protein-ligand structures and their dynamics utilizing advanced mass spectrometric techniques. Cell signaling unit examines the linkages of cellular signaling to the metabolism of cancer cells using molecular biology and biochemistry methods. Through the collaboration of the two groups a unique research platform is formed, wherein the results obtained by the study of biological systems can also be verified and explained at the molecular level. Laboratory is located at the BIOCEV center in Vestec.

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