News:

  • 2022/09/13:

    Insight into the role of site-specific phosphorylation of human antioxidant and disease-associated flavoprotein NQO1 provided through great collaboration with teams of Angel L. Pey and Milagros Medina. Paper now available in Arch Biochem Biophys. Thanks EU FT-ICR MS (H2020) for support.

  • 2022/09/09:

    Congratulations to Bára on succesfull (and very nice) master thesis defense!

  • 2022/08/30:

    Nice work with Moshe and Yoni, this time on tweety proteins is finally out. Freely available in Commun. Biol.! Emelia and guys, thanks for great collaboration and thanks EU FT-ICR MS (H2020) for support.

  • 2022/07/21:

    Our work on top-down FPOP, highlighting the benefits of exact gas-phase isolation of selected protein species and multiple fragmentation modes, is now available in the Analytical Chemistry!

  • 2022/06/22:

    Another popularization event with Aleš & Co. participation - Věda Fest!

  • 2022/06/10:

    Congratulations to Aleš on becoming a group leader at the 1st Faculty of Medicine where he will continue with Víťa in their adventures. Good luck! We enjoyed the time together and are glad that we stay in close contact and will still work together.

Horizon 2020
EPIC-XS
EU FT-ICR MS MSCA

Important:

  • 2022/07/22:

    Synopsis of Ales' Hippostruct MSCA project is available here.

  • 2022/04/22:

    Are you interested in structural mass spectrometry, method development ad/or membrane proteins? We are looking for Bc, MSc, PhD students and post-doc! Inquiries should be addressed to Petr Novak.

About laboratory



Laboratory of Structural Biology and Cell Signaling consists of a multidisciplinary team whose thematic focus is divided into two main directions. Structural biology group produces proteins by recombinant expression technologies and characterizes the protein or protein-ligand structures and their dynamics utilizing advanced mass spectrometric techniques. Cell signaling unit examines the linkages of cellular signaling to the metabolism of cancer cells using molecular biology and biochemistry methods. Through the collaboration of the two groups a unique research platform is formed, wherein the results obtained by the study of biological systems can also be verified and explained at the molecular level. Laboratory is located at the BIOCEV center in Vestec.

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