News:

  • 2022/07/21:

    Our work on top-down FPOP, highlighting the benefits of exact gas-phase isolation of selected protein species and multiple fragmentation modes, is now available in the Analytical Chemistry!

  • 2022/06/22:

    Another popularization event with Aleš & Co. participation - Věda Fest!

  • 2022/06/10:

    Congratulations to Aleš on becoming a group leader at the 1st Faculty of Medicine where he will continue with Víťa in their adventures. Good luck! We enjoyed the time together and are glad that we stay in close contact and will still work together.

  • 2022/06/04:

    Our PhDs lead by Aleš were presenting at the Science Fair (Veletrh vědy). Great event! Some pictures here - one, two, three... ;)

  • 2022/06/02:

    Another great paper on NQO1, now about cavity making mutantions and allostery in flavoproteins. Excellent multilaboratory collaboration lead by Angel L. Pey from the University of Granada. Thanks to EPIC-XS H2020 Project for support!

  • 2022/05/19:

    This is big. Fantastic collaboration with Moshe and Yoni on cis-prenyltransferase continues with another great outcome. Paper now published in Sci. Adv. reveals how these enzymes synthesize long products via small active site!

Horizon 2020
EPIC-XS
EU FT-ICR MS MSCA

Important:

  • 2022/07/22:

    Synopsis of Ales' Hippostruct MSCA project is available here.

  • 2022/04/22:

    Are you interested in structural mass spectrometry, method development ad/or membrane proteins? We are looking for Bc, MSc, PhD students and post-doc! Inquiries should be addressed to Petr Novak.

About laboratory



Laboratory of Structural Biology and Cell Signaling consists of a multidisciplinary team whose thematic focus is divided into two main directions. Structural biology group produces proteins by recombinant expression technologies and characterizes the protein or protein-ligand structures and their dynamics utilizing advanced mass spectrometric techniques. Cell signaling unit examines the linkages of cellular signaling to the metabolism of cancer cells using molecular biology and biochemistry methods. Through the collaboration of the two groups a unique research platform is formed, wherein the results obtained by the study of biological systems can also be verified and explained at the molecular level. Laboratory is located at the BIOCEV center in Vestec.

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