Laboratory of Structural Biology and Cell Signaling

2022/05/19:
This is big. Fantastic collaboration with Moshe and Yoni on cis-prenyltransferase continues with another great outcome. Paper now published in Sci. Adv. reveals how these enzymes synthesize long products via small active site!
2022/02/14:
Happy to help Klara and her team (KH lab) with the work deciphering evolution of early protein-RNA interaction. Paper supported by Terka and The Boss is now in high-ranking Mol. Biol. Evol. journal!
2022/02/09:
Marok's work on FPOP combined with top-down for transcription factor::dsDNA interaction is now published in Anal. Chem.! Very nice complement to our previus HDX and X-linking studies, now with residue level resolution.
2021/12/08:
Our team is growing! Welcome Maartje and Michael! We now have two real experts to expand MS into a second dimension and shoot the protein ions with all electron and laser guns we have. Top-down era of our lab is now making a huge leap forward.
2021/12/06:
Happy news! We received funding from the Czech Science Foundation to expand structural proteomics tools by developing new reagents, enhancing the existing ones and diving into transmembrane proteins.
2021/12/01:
Great success of Jarin and Fiji who have their protein fast-fluoralkylation tricks now published in prestigious J Am Chem Soc. Also thanks for fruitful collaboration - Beier group and CF Plus Chemicals.

2022/04/22:
Are you interested in structural mass spectrometry, method development ad/or membrane proteins? We are looking for Bc, MSc, PhD students and post-doc! Inquiries should be addressed to Petr Novak.